Journal article
Comparing perilymph proteomes across species
JC Palmer, MS Lord, JL Pinyon, AK Wise, NH Lovell, PM Carter, YL Enke, GD Housley, RA Green
Laryngoscope | Published : 2018
DOI: 10.1002/lary.26885
Abstract
Objectives/Hypothesis: Biological components of perilymph affect the electrical performance of cochlear implants. Understanding the perilymph composition of common animal models will improve the understanding of this impact and improve the interpretation of results from animal studies and how it relates to humans. Study Design: Analysis and comparison of the proteomes of human, guinea pig, and cat perilymph. Methods: Multiple perilymph samples from both guinea pigs and cats were analysed via liquid chromatography with tandem mass spectrometry. Proteins were identified using the Mascot database. Human data were obtained from a published dataset. Proteins identified were refined to form a prot..
View full abstractGrants
Awarded by Cochlear
Funding Acknowledgements
This research supported by ARC Linkage grant LP140100109 and Cochlear Ltd. A.K.W. is funded by the Australian National Health and Medical Research Council (GNT 1064375). Bionics Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program. Mass spectrometric analysis for this work was carried out at the Bioanalytical Mass Spectrometry Facility, University of New South Wales, and was supported in part by infrastructure funding from the New South Wales government as part of its coinvestment in the National Collaborative Research Infrastructure Strategy.